This is difficult because it is not the most lucrative area physicians hope to use antibiotics rarely and as a last line of defense. There are very few antibiotics in the development pipeline, so there needs to be more investment in research and development. If we cannot treat a patient who has a nonfunctional immune system, it puts us in a tough place. At some point, they may encounter a bacterium that is resistant to that antibiotic, and we hope that there is a backup antibiotic available.
We prescribe a broad-spectrum antibiotic to such immunocompromised patients. Neutrophils form a barrier in the gut lining, and if a patient lacks these cells, bacteria can translocate from the colon to the bloodstream, causing an infection. Patients who have their immune systems diminished by cancer treatments often present with infections initially related to gut bacteria. How do antimicrobial resistant microbes come to infect cancer patients? I also put those microbes into mice to understand the pathways affecting the immune cells. I analyze patient samples to determine what microbes and metabolites facilitate this response. The gut microbiome influences the response of many tumor types to checkpoint inhibitors. We look forward to your feedback.įyza Shaikh How do you study the role of microbes during cancer treatment? I hope you enjoy this product of our passion and hard work.
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